Electrophysiology Catheters

For Animal Use Only

The EPR-800 electrophysiology catheter is the latest addition to Millar’s line of ultra-miniature catheters for use in transgenic mouse research. At only 1.1F (0.36 mm), this sturdy, ultra-miniature and reusable eight-electrode catheter lends itself to use with transgenic mice as small as 2.5 grams.

Click here for a detailed product table.

Click on product model name for more details.

Model Number	Material	Subject	Length	Tip French	Electrode Spacing	No. of Electrodes	Tip	Pigtail	Use Life	Repairable
EPR-800	Nylon and Polyimide	Mouse	4.5 cm	1.1F	1 mm	8	Straight	No Pigtail	Reusable - Non-Sterile	No
EPR-801	Nylon and Polyimide	Mouse	4.5 cm	1.1F	1 mm	8	Straight	No Pigtail	Reusable - Non-Sterile	No
EPR-802	Nylon and Polyimide	Rat	12.5 cm	1.6F	1 mm	8	Straight	No Pigtail	Reusable - Non-Sterile	No

EP Introduction Sites

The ultra-miniature size of the Millar EP catheters allows them to be introduced invasively or minimally invasively to various sites of the animal, including:

• Jugular vein for placement inside the right atrium and right ventricle
• Esophagus for placement next to the heart
• Carotid artery for placement inside the left ventricle

The EPR-800 catheter can be used for invasive intracardiac electrophysiology studies in mice as young as five days old and in even younger mice following minimally invasive transesophageal electrophysiology studies.

EPR-800 Applications

Standard electrophysiology studies are performed with the EPR-800 catheter by applying pacing and recording protocols from inside the heart or through the esophagus to determine electrical properties of the atrium and the ventricle. Programmed electrical stimulation is also applied through the catheter for induction of abnormal heartbeats.

The following transesophageal recording was taken from a mouse weighing 4 grams, and the intracardiac recording was taken from a mouse weighing 22 grams. Both transesophageal and intracardiac bipolar electrograms were recorded using the EPR-800 catheter, with the distal pair of electrodes predominantly recording ventricular electrical activity and the proximal pair recording atrial activity.

Transesophageal and Intracardiac Electrograms

EPR Catheter System Hardware and Software Options

The EPR-800 catheter is designed to connect to commercially available amplifiers, stimulators and data acquisition hardware. Many of the manufacturers also supply the necessary software to acquire, store and analyze information from the EPR-800 electrophysiology catheter.

Millar recommends using ADInstruments products for transgenic mice research.

Standard Parameters Determined via the EPR-800 Catheter

• Conduction times
• Refractory periods
• His potentials
• Sinus and atrioventricular nodal properties
• Inducibility of abnormal heartbeats

Interface Cables

For more information on Millar electrophysiology catheters or to request a quote, call 832.667.7000 or complete our contact form.