Electrophysiology Catheters

 

The EPR-800 electrophysiology catheter is the latest addition to Millar’s line of ultra-miniature catheters for use in transgenic mouse research. At only 1.1F (0.36 mm), this sturdy, ultra-miniature and reusable eight-electrode catheter lends itself to use with transgenic mice as small as 2.5 grams.

Click on product model name for more details.

Model Number Material Subject Length Tip French Electrode Spacing # Electrodes Tip
EPR-800 Nylon and Polyimide Mouse 4.5 cm 1.1F 1 mm 8 Straight
EPR-801 Nylon and Polyimide Mouse 4.5 cm 1.1F 1 mm 8 Straight
EPR-802 Nylon and Polyimide Rat 12.5 cm 1.6F 1 mm 8 Straight


EP Introduction Sites

The ultra-miniature size of the Millar EP catheters allows them to be introduced invasively or minimally invasively to various sites of the animal, including:

  • Jugular vein for placement inside the right atrium and right ventricle
  • Esophagus for placement next to the heart
  • Carotid artery for placement inside the left ventricle

The EPR-800 catheter can be used for invasive intracardiac electrophysiology studies in mice as young as five days old and in even younger mice following minimally invasive transesophageal electrophysiology studies.

EPR-800 Applications

Standard electrophysiology studies are performed with the EPR-800 catheter by applying pacing and recording protocols from inside the heart or through the esophagus to determine electrical properties of the atrium and the ventricle. Programmed electrical stimulation is also applied through the catheter for induction of abnormal heartbeats.

The following transesophageal recording was taken from a mouse weighing 4 grams, and the intracardiac recording was taken from a mouse weighing 22 grams. Both transesophageal and intracardiac bipolar electrograms were recorded using the EPR-800 catheter, with the distal pair of electrodes predominantly recording ventricular electrical activity and the proximal pair recording atrial activity.

Transesophageal Electrograms Intracardiac Electrograms

Transesophageal and Intracardiac Electrograms

 

EPR Catheter System Hardware and Software Options

The EPR-800 catheter is designed to connect to commercially available amplifiers, stimulators and data acquisition hardware. Many of the manufacturers also supply the necessary software to acquire, store and analyze information from the EPR-800 electrophysiology catheter.

Millar recommends using ADInstruments products for transgenic mice research.

Standard Parameters Determined via the EPR-800 Catheter

  • Conduction times
  • Refractory periods
  • His potentials
  • Sinus and atrioventricular nodal properties
  • Inducibility of abnormal heartbeats

Interface Cables

Cable Model Part Number Cable Length Control Unit Connector
EPC-5A 850-5098 5 ft (152 cm) Redel
EPC-5UT 850-5102 10 ft (304 cm) Unterminated
EPE-3A 850-5111 3 ft (91.4 cm) Redel

 

 

For more information on Millar electrophysiology catheters or to request a quote, call 832.667.7000 or complete our contact form.