Pressure-Volume Loop Systems | Millar Instruments

Animal Use Only

Millar pressure-systems can be used to measure a multitude of parameters including cardiac output, elastance and contractility The market leading Millar Pressure-Volume Systems (MPVS) simultaneously and continuously measure high-fidelity ventricular pressure and volume from the intact beating hearts of animals ranging in size from transgenic mice to livestock. The MPVS measures high fidelity pressure, volume and intracardiac ECG via a single catheter, which combines a Millar pressure sensor with four to twelve conductance electrodes. The cardiovascular pressure and volume signals can be plotted against each other in real time, generating the characteristic left or right ventricular pressure-volume (PV) loops. These are an excellent representation of the cardiac cycle and yield key information regarding normal or diseased conditions of the heart.

In addition, the Millar MPVS systems are backed by Millar’s 40 years of experience in pressure and pressure-volume product development. The result is the highest quality product training and technical support available worldwide. Millar’s knowledgeable representatives and qualified international distributors provide the support you need to integrate pressure-volume data into your high-level cardiovascular research protocols.

Pressure-Volume loop parameters include:	Pressure-Volume applications include:
Contractility Index (ESPVR) Elastance (EDPVR) Cardiac Output Stroke Volume Max and Min Ventricular dP/dt Pre-load Recruitable Stroke Work (PRSW) Ejection Fraction Tau Time-Varying Maximum Elastance E(t) End-Systolic Elastance (Ees) Max and Min dV/dt Arterial Elastance (Ea)	Baseline PV loop analysis Occlusion PV loop analysis Phenotyping gene manipulations Cardiac hypertrophy Cardiac failure Cardiovascular remodeling Toxicology Pharmacology (rapid drug screening) Cardiac resynchronization therapy Surgical interventions Ischemia/reperfusion studies Vascular occlusions Transgenic manipulation

Pressure-Volume Solutions

Millar offers two complete solutions for the pressure-volume researcher, the MPVS Ultra^® Single Segment system and the full MPVS Ultra^® system. Both systems utilize the same proven Millar conductance technology and provide a simple, streamlined software interface for setup and calibration.

The MPVS Ultra systems provide proven flexible calibration options for both small and large animal PV studies. Both systems can be combined with commonly available technologies to provide a real-time, absolute volume output while also maintaining the integrity of the original conductance data.

When combined with the ADInstruments PowerLab 16/35 16-channel data acquisition system, ADInstruments LabChart Pro software, and Millar’s high quality pressure-volume catheters, the MPVS Ultra provides the ideal solution for complete cardiac function assessment in a wide range of animal models. This configuration is perfect for the core facility or collaborative labs interested in combining resources to acquire a single platform to meet their cardiovascular research needs.

MPVS Ultra Single Segment

As the pioneering company for pressure-volume research, Millar provides the first and only upgradeable hardware solution to meet your evolving research needs. The MPVS Ultra Single Segment provides the most economical solution to rodent pressure-volume studies on the market today. This system includes two pressure amplifiers, a single segment of volume measurement, intracardiac ECG and intuitive software control at a fraction of the cost of comparable imaging technologies.

As your research evolves from rodent studies to larger animal models, your MPVS Ultra Single Segment unit can evolve with you via a simple software upgrade. This will unlock the full capability of the MPVS Ultra system and allow volume measurement across up to seven electrode segments using Millar Ventri-Cath multi-segment pressure-volume catheters. Contact a Millar representative to upgrade or inquire about upgrading your MPVS Ultra Single Segment unit.

MPVS Ultra

The MPVS Ultra system is the only solution for assessing complete cardiac function in animal models ranging in size from mice to livestock. The system is compatible with Millar’s complete line of small animal pressure-volume catheters and large animal Ventri-Cath pressure-volume catheters.

The MPVS Ultra includes two pressure amplifiers, up to seven segments of volume measurement, intracardiac ECG and intuitive software control for simple optimization of catheter placement within the ventricle.

Pressure-Volume Catheters

Millar’s pressure-volume catheters provide comprehensive cardiac function assessment for animal research studies.

Simultaneous high-fidelity pressure and volume measurements from a single catheter
1 to 6 French catheter tip sizes for use in small mice to domestic livestock
Single-field or dual-field configurations to accommodate various heart sizes
Dual pressure sensor models available
Designed for use with MPVS Ultra^® pressure-volume system
Applicable for closed-chest or open-chest surgical procedures as well as isolated working heart studies

PVAN Analysis Software

Uses pressure and volume data in a variety of hemodynamic calculations to assess cardiac performance.

Variety of displays and calculation tables
Integration with ADInstruments Chart
Easy data export
Built-in cuvette calibration

Accessories

The complete MPVS Ultra^® is available through Millar as well as a selection of Pressure Control Units and cables that interface Millar Mikro-Tip^® catheter pressure transducers to physiological monitors. All accessories are sold separately.

For more information on the Millar Pressure Volume Systems or to purchase, call 832.667.7000 or complete our contact form.