The EPR-800 electrophysiology catheter is the latest addition to Millar’s line of ultra-miniature catheters for use in transgenic mouse research. At only 1.1F (0.36 mm), this sturdy, ultra-miniature and reusable eight-electrode catheter lends itself to use with transgenic mice as small as 2.5 grams.
The ultra-miniature size of the Millar EP catheters allows them to be introduced invasively or minimally invasively to various sites of the animal, including:
The EPR-800 catheter can be used for invasive intracardiac electrophysiology studies in mice as young as five days old and in even younger mice following minimally invasive transesophageal electrophysiology studies.
Standard electrophysiology studies are performed with the EPR-800 catheter by applying pacing and recording protocols from inside the heart or through the esophagus to determine electrical properties of the atrium and the ventricle. Programmed electrical stimulation is also applied through the catheter for induction of abnormal heartbeats.
The following transesophageal recording was taken from a mouse weighing 4 grams, and the intracardiac recording was taken from a mouse weighing 22 grams. Both transesophageal and intracardiac bipolar electrograms were recorded using the EPR-800 catheter, with the distal pair of electrodes predominantly recording ventricular electrical activity and the proximal pair recording atrial activity.
The EPR-800 catheter is designed to connect to commercially available amplifiers, stimulators and data acquisition hardware. Many of the manufacturers also supply the necessary software to acquire, store and analyze information from the EPR-800 electrophysiology catheter.
Millar recommends using ADInstruments products for transgenic mice research.
|Cable Model||Part Number||Cable Length||Control Unit Connector|
|EPC-5A||850-5098||5 ft (152 cm)||Redel|
|EPC-5UT||850-5102||10 ft (304 cm)||Unterminated|
|EPE-3A||850-5111||3 ft (91.4 cm)||Redel|