FOR ANIMAL USE ONLY
With a combined 85+ years of experience in research excellence, ADInstruments and Millar ensure you have the right technology and support to unlock new insights and push the boundaries of discovery.
Comprehensive data leads to more powerful insights. That’s why Millar is at the forefront of cardiovascular research, supporting leading efforts worldwide with innovative instrumentation like the MPVS Duo™ for complete pressure-volume (PV) loop analysis. Our Pressure-Volume Loop Systems feature:
Capture synchronized pressure-volume loops instantly.
Ideal for mouse and rat models; catheter sizes designed for pre-clinical research.
Analyze load-independent indices using LabChart or PV Loop software with built-in calculations.
Solid-state catheters reduce recalibration time and improve repeatability.
Compatible with Millar’s complete line of small-animal PV loop catheters and large-animal Ventri-Cath® PV loop catheters, the MPVS Duo delivers robust and repeatable cardiovascular measurements for researchers around the world.
For complete pressure-volume (PV) loop analysis in both large and small animal models, Millar’s PV loop catheters integrate seamlessly with the MPVS Duo system. These catheters combine high-fidelity pressure sensors and electrodes for simultaneous, real-time pressure and volume measurements, enabling minimally invasive, continuous intracardiac PV analysis with unprecedented accuracy and precision.
| Model | Subject | Tip | Tip F Size | # of Sensors | Electrode Spacing | Length |
|---|---|---|---|---|---|---|
| SPR-839 | Mouse | Straight | 1.4F | 1 | 4.5 mm | 3.5 cm |
| PVR-1045 | Mouse | Straight | 1F | 1 | 4.5 mm | 3.5 cm |
| PVR-1035 | Mouse | Straight | 1F | 1 | 3.5 mm | 3.5 cm |
| PVR-1030 | Mouse | Straight | 1F | 1 | 3 mm | 3.5 cm |
| SPR-838 | Rat | Straight | 2F | 1 | 9 mm | 12.5 cm |
| SPR-869 | Rat | Straight | 2F | 1 | 6 mm | 12.5 cm |
| Ventri-Cath 507 | Pig and Sheep | Pigtail or Straight | 5F | 1 | 7 mm | 120 cm |
| Ventri-Cath 510 | Pig and Sheep | Pigtail or Straight | 5F | 1 | 10 mm | 120 cm |
| Ventri-Cath 512 | Pig and Sheep | Pigtail or Straight | 5F | 1 | 12 mm | 120 cm |
| Ventri-Cath 515 | Pig and Sheep | Pigtail or Straight | 5F | 1 | 15 mm | 120 cm |
A PV loop system measures cardiac function by recording pressure and volume changes in the left or right ventricle throughout the cardiac cycle. It provides critical insight into cardiac contractility, compliance, preload, afterload, and more.
The MPVS Duo system offers real-time, high-fidelity pressure and volume signals using Millar’s Mikro-Tip conductance catheters. It’s designed for use in all animal models and integrates seamlessly with data acquisition platforms like LabChart for full cardiovascular analysis.
Yes. Millar offers a wide range of Mikro-Tip catheter sizes to support small and large animal models — from mice and rats to pigs and dogs — making the system ideal for translational research.
Millar PV loop systems are designed to work with LabChart software by ADInstruments. LabChart’s PV Loop Module provides tools for automated data acquisition, analysis and visualization of key hemodynamic parameters.
Volume calibration is achieved using a combination of admittance measurements, parallel conductance correction (via hypertonic saline or cuvette methods), and other model-specific techniques. Millar offers guidance and tools for accurate calibration.
Millar and ADInstruments provide extensive onboarding support, including setup assistance, user manuals, video tutorials, and access to experienced technical specialists for training and troubleshooting.
The MPVS Duo is primarily designed for acute studies, though certain components can be adapted for chronic protocols depending on study design and species. Millar can advise on best practices for your use case.
For more information on how Millar and ADInstruments are working together to provide precise pressure and pressure volume research results, please download the Accuracy Matters brochure.
