PV Loop Research Applications

Pressure-volume (PV) loop studies provide researchers with comprehensive, load-independent data regarding normal and diseased conditions of the heart. With an in-depth view of the complete cardiac cycle, insights can be gained in heart failure models, valvular disease, and basic cardiovascular research. With over 30 different hemodynamic parameters, PV loop data can easily advance research studies to the next level.

PV Loop Studies Deliver Direct
In-Depth Data

A diagram explaining how the Millar Pressure-volume loop system works. Known as the gold-standard method for measuring direct, real-time, complete cardiac function, Millar's pressure-volume (PV) loop system delivers instant cardiovascular function feedback. PV loop studies provide researchers with comprehensive independent data regarding normal and diseased conditions of the heart by generating the characteristic left or right ventricular pressure-volume (PV) loops.

A single PV loop is created by plotting pressure and volume signals against each other in real time, with one loop representing the complete cardiac cycle. PV loops provide instant cardiovascular function feedback based on its morphology, position, and timing. Only left or right ventricular PV loops can provide beat-to-beat and full diastolic analysis from a single, minimally invasive catheter. Millar offers pressure-volume loop technology for both research and clinical applications.

Cutting-edge PV Loop studies have a wide variety of research applications in both large and small animal models, including:

PV Loops = More Cardiovascular Data

Parameter Description Parameter Description Parameter Description
HR Heart Rate Ea Arterial Elastance dP/dt min Minimum dP/dt
Vmax Maximum Volume CO Cardiac Output dV/dt max Maximum dV/dt
Vmin Minimum Volume SW Stroke Work dV/dt min Minimum dV/dt
Ves End-Systolic Volume SV Stroke Volume P@dP/dt max Pressure at dP/dt Max
Ved End-Diastolic Volume EF Ejection Fraction P@dV/dt max Pressure at dV/dt Max
Pmax Maximum Pressure PRSW Preload Recruitable SW V@dP/dt max Volume at dP/dt Max
Pmin Minimum Pressure ESPVR End-Systolic PV Relationship V@dP/dt min Volume at dP/dt Min
Pes End-Systolic Pressure EDPVR End-Diastolic PV Relationship Tau (Weiss) Tau-Weiss Method
Ped End-Diastolic Pressure E(t) Time-Varying Maximum Elastance Tau (Glantz) Tau-Glantz Method
Ees End-Systolic Elastance dP/dt max Maximum dP/dt Tau (Logistic) Tau-Logistic Method

PV Loops: Mouse to Man

Dr. Navin Kapur, Assistant Professor and Assistant Director of the Interventional Cardiology Center at Tufts Medical Center, discusses his experience utilizing PV loop data in cardiovascular applications from mouse to man. Additionally, Dr. Kapur provides perspective on how PV Loops can be used as a tool for the interventional cardiologist and during the evaluation of advanced heart failure.

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Millar and ADInstruments

Millar Mikro-Tip® Pressure and PV Loop catheters systems are available exclusively from ADInstruments. Our strategic partnership enables an extended capacity for global reach while strengthening local support for all Millar customers. Millar and ADInstruments have been business partners for over 15 years. Both companies share the same goals of providing quality products backed by world-class technical support and service.

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Explore Millar's online Knowledge Center where you will find our latest product support and OEM integration resources, including White Papers, Application Notes, Webinars, Partner Success Stories, Manuals and Guides, Videos, Software Downloads and Demos, Training Materials and much more.

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Contact Millar

For more information on the different applications of our PV Loop products or for inquiries on how to purchase, please visit our contact page and get in touch with us. 

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