Mitral regurgitation (MR) is the most common form of valvular heart disease. The mitral clip procedure is a catheter-based therapy that provides a less invasive alternative for surgical mitral valve repair. In this procedure, one or more metal clips are deployed to create a double orifice mitral valve by clipping the leaflets together to reduce mitral regurgitation.
Recent clinical data by Gaemperli et al.¹ demonstrated the use of pressure-volume (PV) loops to provide real-time monitoring of the hemodynamic effects of mitral regurgitation reduction on the LV during Mitral Clipping. In their clinical perspective, the authors stated, “Real-time pressure-volume measurements may be used to monitor immediate changes in LV loading conditions and contractility during the MitraClip procedure, particularly in high-risk patients with low ejection fraction.” Therefore, it may shorten the procedure by the real-time evaluation of acute decreases in mitral regurgitation, eventually avoiding the placement of more than one clip.
The examples below show the acute improvement in LV function following the Mitral Clip procedure according to the end-systolic pressure-volume relationship.
Reference: Gaemperli et al. Real-time left ventricular pressure-volume loop during percutaneous mitral valve repair with the MitraClip system. Circulation 2013;127:1018-1027